KMID : 1035320140410040263
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Korean Society for Dental Materials 2014 Volume.41 No. 4 p.263 ~ p.272
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The Influence of Diabetes Mellitus on Expression of Stromelysins and Membrane type Matrix Metalloproteinases in Human Chronic Periodontitis
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Ryu Sang-Ho
Lee Jae-Mok
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Abstract
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The purposes of this study were to observe influence of diabetes mellitus(DM) on the expression of MMP?3 of stromelysin type and MMP?14 of membrane type matrix metalloproteinase in the gingival tissues of patients with type 2 DM and healthy adults with chronic periodontitis. Gingival samples were devided into three groups. Group 1 is clinically healthy gingiva without bleeding, bone resorption or periodontal pockets. Group 2 is inflammed gingiva from patients with chronic periodontitis. Group 3 is inflammed gingiva from patients with chronic periodontitis associated with type 2 DM. Tissue samples were analyzed by Western blotting. The quantification of MMP?3 and MMP?14 were performed using a densitometer. MMP?3 and MMP?14 expressions were similar in group 1 and 2. While expression of MMP-14 increases in proportion to MMP-3 expression, expression of both type of MMP showed increasing tendency in chronic periodontitis associated to type 2 DM and mean amount of it was more increased in group 3 comparing to other group with statistically significant difference.
In conclusion, MMP?3 and MMP?14 expression levels were similar in healthy and inflamed gingival tissue from systemically healthy patients. And tissue with chronic periodontitis associated to type 2 DM showed significantly increased MMP?3 and MMP?14 levels compared to healthy and non?diabetic inflamed gingiva. Also, MMP?3 may be related to MMP?14 activity in chronic periodontitis associated with type 2 DM. Therefore, the expression levels of MMP?3 and MMP?14 will be inflammatory markers of periodontal inflammed tissue with type 2 DM.
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KEYWORD
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chronic periodontitis, MMP-3, MMP-14, Type 2 Diabetes Mellitus
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